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• Abdominal discomfort
• Food allergies
• Irritable bowel syndrome (IBS)
The IPA Analysis is a uniquely comprehensive test designed to determine the health and efficiency of multiple gastrointestinal functions. Of specific interest are increased intestinal permeability, intestinal damage, gut function, lactose intolerance, sucrose intolerance, and the health of intestinal villi.
The theory behind the IPA test has been comprehensively reviewed, and by evaluating the past 30 years scientific literature, it is now possible to obtain a more in-depth understanding about intestinal function. The IPA test differs from other intestinal permeability tests in that it analyses five types of sugar and their correlative enzymes as opposed to only two types. With two sugars you are getting perhaps just two-fifths of the clinical picture.
The IPA test provides an indication as to whether a patient suffers from one or more of the following clinical conditions: reduced absorption capacity; increased gastrointestinal permeability; inflammation; or lactose and sucrose intolerance – knowledge not previously obtainable from the two sugar tests. The test is carried out following the ingestion of a sugar solution containing the five different types of sugar: mannitol, sucrose, lactose, rafinose and cellobiose. The concentrations of the different sugars are identifiable in urine. The levels or their mutual ratios indicate whether the above clinical conditions are prevalent.
Increased Intestinal Permeability
Increased intestinal permeability syndrome is a condition caused by damage to the mucosal lining of the intestines. The intestines are designed to absorb nutrients as small molecules (molecular radius <40nm). When the bowel lining is altered or damaged, larger, undigested molecules are absorbed into the bloodstream and cause further inflammation, consequently inhibiting the absorption of beneficial nutrients. Increased intestinal permeability is primarily caused by overconsumption of alcohol, carbonated drinks, pharmaceutical drugs, and diets consisting of low-fiber, high-fructose, preserved, and processed foods. The effects can be varied and severe, ranging from fatigue and bloating to heightened food allergies, protein damage, detoxification inhibition, and a weakened immune system. Unfortunately, many of these symptoms are unrecognized, and many cases of increased intestinal permeability are undiagnosed.
Average processing time:
17 ±8 days
• Assessment of Hypolactasia and Site-Specific Intestinal Permeability by Differential Sugar Absorption of Raffinose, Lactose, Sucrose and Mannitol
• Got Guts? Need Nerve! (Enteric glia regulate intestinal barrier function and inflammation via release of s-itrosoglutathione)
• Hessels J, Snoeyink E, Platenkamp A, Voortman G, Steggink J, Eidhof H. Assessment of Intestinal Permeability: Enzymatic Determination of Urinary Mannitol, Raffinose, Sucrose and Lactose on Hitachi Analyzer. Clinical Chemistry and Laboratory Medicine. 2003;41(1).
• Hessels J, Eidhof H, Steggink J et al. Assessment of Hypolactasia and Site-Specific Intestinal Permeability by Differential Sugar Absorption of Raffinose, Lactose, Sucrose and Mannitol. Clinical Chemistry and Laboratory Medicine. 2003;41(8).
• Pasini E, Aquilani R, Testa C et al. Pathogenic Gut Flora in Patients With Chronic Heart Failure. JACC: Heart Failure. 2016;4(3):220-227.
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Nordic Laboratories · Nygade 6 · 3.sal · 1164 Copenhagen K · Denmark