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A baseline view of how a patient is metabolizing estrogens. Estrogens are essential for health and well being in both women and men. However, some oxidized estrogen metabolites have been shown to be harmful and potentially increase risk for breast cancer in women, and potentially prostate cancer in men. Because urine has the highest concentration of these estrogen metabolites compared to any other body fluid, urine has been the fluid of choice to monitor the estrogen metabolites. Moreover, selected progesterone metabolites are included in the test. Very little progesterone itself enters the urine, whereas progesterone metabolites are readily excreted in urine. One of the primary progesterone metabolites is a glucuronide conjugate of pregnanediol. Levels of this progesterone metabolite are very similar to active levels of progesterone in the bloodstream, making pregnanediol a convenient surrogate marker of progesterone synthesis.

Selected androgens and androgen metabolites provide an insight on androgen status and metabolism.


  • A wide array of estrogen, progesterone, and androgen metabolites useful for assessment of breast cancer risk 
  • Glucocorticoid metabolites, diurnal free cortisol, and diurnal free cortisone for adrenal assessment 
  • Diurnal 6-sulfatoxymelatonin (MT6s) to assess sleep / wake cycle dysfunction
  • The xenoestrogen Bisphenol A (BPA)